In Reincardnated each player starts the game as a 'Starter Being', one of ten plants in the game. Players are then given a hidden 'Life Purpose' card which relays goals and being types players should try to incarnate through gameplay.

During gameplay, players take turns incarnating one of 54 unique beings which create each player's Life Line. By incarnating beings, players gain 'Karma' cards. These 'Karma' cards allow players to impact their own 'Life Lines' and their opponents such as killing/reviving beings, forcing unexpected incarnations and viewing 'Life Purposes' to better strategize.

When a player incarnates the 'Human Form', game play comes to an end. From here players reveal their unique 'Life Purpose' cards and add up their scores. Highest score wins.